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A Note on Photography and the Simulacral by Rosalind Krauss

By Rosalind Krauss

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During different reproductive stages female rats experience different pain thresholds, suggesting that the hormonal environment may modulate their nociceptive responses. The proposed studies will examine pain and opioid sensitivity in ovariectomized (OVX) rats with and without steroid replacement Behavior and gene expression will be concurrently examined. We will measure not only the response to an acute thermal stimulus (tail flick) but also models of subacute (formalin and intrathecal, IT NMDA) and chronic (nerve constriction) nociception and a test for mechanical sensitivity.

Phosphorylation) and determine its possible relationship to morphine tolerance. , tolerance). We also plan to pinpoint the exact phosphorylation sites of cloned opioid receptors which are involved in receptor desensitization as well as to determine the protein kinases (or other protein factors) that are involved in this process. ; Professor; Arkansas Children's Hospital Res Inst Research Institute Little Rock, Ar 72202 Timing: Fiscal Year 2001; Project Start 01-JUN-1999; Project End 31-MAY-2004 Summary: This abstract is not available.

The requirement for protein synthesis of addictive memories is virtually unknown. Here we propose to address several fundamental questions that will target the protein synthesis-dependent processes of addictive memory and other addictive behaviors. The results of these experiments will lay a foundation for further studies, which will examine molecules, pathways and pharmacological intervention in addiction. These investigations may produce significant breakthroughs that could help in the development of new therapies for drug addiction.

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