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Achalasia: Diagnosis and Treatment by P. Marco Fisichella, Fernando A. M. Herbella, Marco G. Patti

By P. Marco Fisichella, Fernando A. M. Herbella, Marco G. Patti

each one bankruptcy describes a truly particular element of Achalasia by way of its identified specialist. present diagnostic and administration techniques of Achalasia, in addition to the simplified operative methods with appropriate technical issues, are defined for the explicit objective audience.

The therapy of Achalasia is complicated and customarily played in really good tertiary-care centres. The Editors' major aim is to render this illness extra comprehensible and obtainable to citizens, fellows, and experts in either the surgical disciplines (general surgical procedure and thoracic surgical procedure) and in gastroenterology.

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Eye. 1988;2(Pt 1):16–23. 7. Lacy BE, Weiser K, Kennedy A. Botulinum toxin and gastrointestinal tract disorders: panacea, placebo, or pathway to the future? Gastroenterol Hepatol. 2008;4(4):283–95. 8. Barr JR, Moura H, Boyer AE, Woolfitt AR, Kalb SR, Pavlopoulos A, et al. Botulinum neurotoxin detection and differentiation by mass spectrometry. Emerg Infect Dis. 2005;11(10):1578–83. 9. Ishikawa H, Mitsui Y, Yoshitomi T, Mashimo K, Aoki S, Mukuno K, et al. Presynaptic effects of botulinum toxin type A on the neuronally evoked response of albino and pigmented rabbit iris sphincter and dilator muscles.

One concern is that BoNT may increase inflammation in the mucosa and muscle planes, and lead to greater difficulty for subsequent myotomy. Studies in pigs showed fibrotic changes in the LES after BoNT injection [44]. However, most histological studies in humans show that there are no significant changes in muscle [45], and post-surgical studies show no significant differences in outcome after BoNT treatment [46]. One abstract with limited number of cases suggests that a prior BoNT may increase perforation risk of subsequent PD [47].

The history of Chagas disease. Parasit Vectors. 2014;7:317–24. 2. Herbella FA, Matone J, Del Grande JC. Eponyms in esophageal surgery, part 2. Dis Esophagus. 2005; 18(1):4–16. 3. Bonney KM. Chagas disease in the 21st century: a public health success or an emerging threat? Parasite. 2014;21:11. 4. Pinotti HW, Felix WN, Zilberstein B, Cecconello I. Surgical complications of Chagas’ disease; 9. 10. 11. megaesophagus, achalasia of the pylorus and cholelithiasis. World J Surg. 1991;15:198–204. Herbella FAM, Oliveira DRC, Del Grande JC.

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