By Robert Lev
Adenomatous Polyps of the Colon: Pathobiological and Clinical Features consolidates the immense physique of uncomplicated technology and medical info linked to adenomatous polyps of the colon, a lot of it encouraged via the belief that almost all colorectal carcinomas appear to come up in such polyps. This e-book strives to judge those information, with specific emphasis on their implications for administration of polyp-bearing topics. themes comprehensively explored comprise anatomy and histology of the conventional colon; pathologic features of adenomatous polyps, differential prognosis, and grading schemes for measure of dysplasia and villosity; adenomatous polyposes; histologic and epidemiologic proof for the malignant power of adenomatous polyps; and detection and administration, with designated cognizance to endoscopy, endoscopic polypectomy, the malignant polyp, and post-polypectomy surveillance schedules.
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Extra info for Adenomatous Polyps of the Colon: Pathobiological and Clinical Features
They stated that 100 percent of APs in nonpolyposis cases and 82 percent of APs in familial polyposis arose in that fashion. In the remaining familial polyposis cases, the fact that adenomas did not originate from deep basal cells could be explained by the exclusive presence of mature goblet cells in the deep crypts from which one would not expect adenomatous epithelium to arise. In such cases, they speculated, the adenomas might have arisen from less differentiated cells in the mid- or upper mucosa.
Lance P, Lev R (1989) Colonic oligosaccharide structure deduced from lectin-binding studies before and after desialylation. (Submitted for publication) Lane N, Kaplan H, Pascal R (1971) Minute adenomatous and hyperplastic polyps of the colon: Divergent patterns of epithelial growth with specific associated mesenchymal changes. Gastroenterology 60:537-551. Lane N, Lev R (1963) Observations on the origin of adenomatous epithelium of the colon. Serial section studies of minute polyps in familial polyposis.
8. Regression of Polyps Occasional patients with familial polyposis exhibit regression of rectal adenomas or absence of new lesions after total colectomy and ileoproctostomy (Cole & Holden, 1959). In a larger series of patients, Bussey (1975) has confirmed this, especially in younger individuals. Possible reasons for this phenomenon include diversion of ileal contents to the rectum, loss of diseased colon, and rectal ischemia. Regression of sporadic polyps has also been described (KnoernschiId, 1963).