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Advances in Mutagenesis Research by V. I. Ivanov, N. A. Liapunova (auth.), Professor Dr. Günter

By V. I. Ivanov, N. A. Liapunova (auth.), Professor Dr. Günter Obe (eds.)

Utilized genetic study, genetic toxicology and mutation study examine the mutagenicity and cancerogenicity of chemical compounds and different brokers. everlasting mutation in genes and chromosomes, might be brought about via aplethora of brokers, together with ionizing and nonionizing radiations, chemical substances, and viruses. one of the elements discused by means of Advances in Mutagenesis learn are (1) the certainty of the molecular mechanisms resulting in mutations, and (2) the prevention of a inconsiderate advent of mutagenic brokers into the surroundings. Contents: Nikolay W. Timofeeff-Ressovsky (1900-1981): An Essay on his existence and clinical Achievements. - Arylnitrenium Ions and the Genotoxic efficiency of fragrant Amines and Nitro Compounds. - Analysisof Mutagenicity and Chemical constitution in quite a few sequence of similar Compounds. - Formation of 8-Hydroxyguanine by means of Oxidative DNA harm, its fix and its Mutagenic results. - Exploring Genetic and Non-Genetic Relationships: The Induction of Micronuclei. - Mechanisms of brought about Mutagenesis via Ultraviolet gentle in Escherichia coli. - Polytene Chromosomes in Mutagenesis. Three-Way Differential Stainingof Chromosomes for the identity of SCEs consistent with phone Cycle: basics and purposes. - The Mammalian Centromere: Centromere Separation, Kinetochore Proteins and Aneuploidy. - Chorionic Villi research. - ExploringGenetic and Non-Genetic Relationships: The Induction of Micronuclei.

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Ozawa and his collaborators observed a very high level of oh 8 Gua (38% of the total guanine) in mouse liver mitochondrial DNA after administration of azidothymidine (Hayakawa et al. 1991a). Age-associated increases of oh 8 Gua in the DNA of rat organs (Fraga et al. 1990) and in mitochondrial DNA of human diaphragm (Hayakawa et al. 1991b) have also Formation of 8-Hydroxyguanine by Oxidative DNA Damage 43 been observed. oh 8 Gua is also produced in DNA of rat organs after administration of chemical carcinogens that form oxygen radicals.

Chern Bioi Interact 57:97-106 Kriek E (1965) On the interaction of N-2-ftuorenylhydroxylamine with nucleic acids in vitro. Biochem Biophys Res Commun 20:793-799 Kriek E (1974) Carcinogenesis by aromatic amines. Biochim Biophys Acta 355:177-203 Lai CC, Miller EC, Miller JA, Liem A (1987) Initiation of hepatocarcinogenesis in infant male B6C3F 1 mice by N-hydroxy-2-aminoftuorene or N-hydroxy-2-acetylaminoftuorene depends primarily on metabolism to N-sulfooxy-2-aminoftuorene and formation of DNA(deoxyguanosin-8-yl)-2-aminoftuorene adducts.

2 Formation of oh BGua in DNA by Oxygen-Radical Forming Agents . . . . . . . 3 Repair of oh BGua Residues in DNA . . . . . . . . . . . . . . . . 4 Induction of Mutations by oh BGua in DNA . . . . . . . . . . . . . . 5 Discussion . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . 31 32 34 40 42 43 1 Introduction In 1982 the analysis of DNA ad ducts was carried out, particularly guanine ad ducts, as one approach to the identification of direct-acting mutagens present in broiled foods and environmental materials.

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