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Extra info for Alzheimer's Disease - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
This peptide is produced in both the brain and peripheral tissues by cleavage from a common cell-surface precursor protein. Soluble beta-amyloid exists free in the blood and cerebrospinal fluid while "insoluble" aggregates are deposited in the brain as amyloid plaques. The soluble and insoluble forms of beta-amyloid present within Alzheimer's patients appear to be in dynamic equilibrium. In the Phase I proposal we described how to displace this equilibrium away from the brain by generating peptide-specific antibodies in a transgenic mouse model of Alzheimer's disease.
Columbia Univ New York Morningside 1210 Amsterdam Ave, Mc 2205 New York, Ny 10027 Timing: Fiscal Year 2003; Project Start 01-APR-2003; Project End 31-MAR-2008 Summary: The developing nervous system is vulnerable to adverse effects due to exposures to a variety of substances in the environment, particularly metals and pesticides. At the same time, chronic exposure to low levels of neurotoxicants throughout life can lead to impaired neurologic functioning later in life, particularly in the elderly.
These criteria are uniformly applied and all data is directly entered into a computerized program at the time of collection. In addition, all stored tissue is indexed using a specimen tracking software program (FreezerWorks) facilitating reliable tissue distribution. The brain tissue and neuropathological data provided to the investigators of Projects 7, 8, 9, and 10 by the Neuropathology Core is critical for the success of the projects, and for the provision of seminal information about changes in the dopaminergic system and the functions of tau protein kinases and galanin in the progression of cognitive impairment in the elderly and those with Alzheimer's disease.