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Additional info for Antioxidants - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
The investigation would take advantage of two large prospective cohorts: the Health Professionals Follow-up Study (HPFS; 51,529 male health professionals followed since 1986), and the Nurses' Health Study (NHS; 121,600 female registered nurses followed since 1976). The occurrence of incident cases of PD in these cohorts is already being documented as part of an NIH funded study (we have Studies 27 confirmed 470 cases, 250 in men and 220 in women, and follow-up is ongoing). Moreover, diet and other lifestyle factors have been repeatedly assessed in these populations, and cognitive tests have already been administered to several thousands of NHS participants without PD (as part of a separate project).
One reason for the greater toxicity of equal masses of these smaller particles is their much greater surface area. We hypothesize that the size of inhaled fine particles, in addition to their chemical and other physical characteristics, plays a critical role in determining occupational health effects. To test this we will study early lung and systemic inflammatory responses as well as cardiac effects in adults after carefully controlled inhalation exposure to ultrafine and accumulation mode zinc oxide, a particle we have previously characterized for the dose-response relationship of its short term pulmonary and systemic inflammatory effects.
By combining expertise from the two independent disciplines of microbiology and pharmaceutical sciences, we have the capability and the know-how to effectively test this complex hypothesis. if proven, this complex metabolic process will have profound impact on safety and efficacy of this herbal extract and other flavonoidrich herbal products. Through future animal and human studies in vivo, we would then determine how this grand recycling scheme influences the disposition of a variety of herbal and pharmaceutical products that also undergo, perhaps repeatedly, enterohepatic recycling.