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Asthma: Immunopathology and Immunotherapy / Immunopathologie by Dr. L. W. Poulter, C. Power, C. Hutter, S. Sreenan, C. Burke

By Dr. L. W. Poulter, C. Power, C. Hutter, S. Sreenan, C. Burke (auth.), Univ.-Prof. Dr. Friedrich Kummer (eds.)

Das Konzept des allergischen bronchial asthma hat lange Zeit so sehr dominiert, da? die Immunotherapie vielfach ohne gesicherte diagnostische Grundlage, halbherzig oder ohne die Feinheiten der Allergenvermeidung angewendet wurde. Die Forschung der letzten zehn Jahre hat uns eine derartige Ausweitung unseres Wissenshorizontes beschert, da? es an der Zeit schien, ma?gebliche Autoren zur gemeinsamen Diskussion der neuen Aspekte einzuladen. Das Buch berichtet von den neuesten Erkenntnissen uber zellulares Verhalten, unterschiedliche Zytokinmuster und autoimmunologische Aspekte bis hin zur modernen Allergenvermeidung, aber auch von der wirksamen medikamentosen Therapie der eosinophilen Entzundung the idea that of bronchial asthma being an "allergic illness in simple terms" has ruled above others to an quantity, second look of this factor within the gentle of very fresh effects from learn in immunopathology appeared greater than late. This quantity presents a present suggestion of conception and medical perform of immunopathology and remedy of bronchial asthma, comprising vast and fresh laboratory facts on atopy, intrinsic bronchial asthma, facets of autoimmunology, in addition to directions for allergen avoidance, immunotherapy and - final no longer least - pharmacological remedy of eosinophilic irritation.

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A third step is the alteration of the responsiveness of the circulating cell to chemotactic and chemokinetic signals. Several studies have shown that chemotactic signals indeed are generated in asthmatics (reviewed in [58, 59] and [52]). What is puzzling is the non-selective nature of these signals. I. e. they will equally well attract eosinophils and neutrophils. It is therefore likely that other mechanisms are responsible for the selection of the type of cell that is ultimately concentrated in the particular tissue.

Pirron U, Schlunck T, Prinz JC, Rieber EP (1990) IgE-dependent antigen focussing by human B lymphocytes is mediated by the low-affinity receptor for IgE. Eur J Immunol20: 1547-1551 9. Mudde GC, Hansel TT, Van Reijsen FC, Osterhoff BF, BruijnzeelKoomen CAFM (1990) IgE: An immunoglobulin specialized in antigen capture. Immunol Today 11: 440-443 10. Bruijnzeel-Koomen CAFM, Boland GJ, Mudde GC (1988) IgE-mediated antigen presentation by epidermal Langerhans cells from patients with atopic dermatitis.

FEBS Letters 189 (2): 350-354 Shaw RJ, Cromwell 0, Kay AB (1984) Preferential generation of leukotriene C4 by human eosinophils. Clin Exp Immunol56: 716-722 Lee TC, Lenihan DJ, Malone B, Roddy LL, Wasserman SI (1984) Increased biosynthesis of platelet-activating factor in activated human eosinophils. J Bioi Chern 259: 5526-5530 Carlson MGCh, Peterson CGB, Venge P (1985) Human eosinophil peroxidase: purification and characterization. lmmunology 50: 19-26 Hallgren R, Venge P (1991) The eosinophil in inflammation.

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