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Benefit-Cost Analysis in Environmental, Health, and Safety by Kenneth J. Arrow

By Kenneth J. Arrow

This primer highlights either the strengths and the constraints of benefit-cost research within the improvement, layout, and implementation of regulatory reform.

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1996. Tryptophan produced by Showa Denko and epidemic eosinophilia-myalgia syndrome. Journal of Rheumatology Supplement 46:81–88. Comment on: Journal of Rheumatology Supplement 1996 46:44–58 and 60–72; discussion 58–59. 10. Mathre ML, Editor. 1997. Cannabis in Medical Practice. Jefferson, NC: MacFarland and Co. 11. Mechoulam R. 1986. The pharmacohistory of Cannabis Sativa. In: Mechoulam R , Editor. Cannabinoids as Therapeutic Agents. Boca Raton, FL: CRC Press. Pp. 1–19. 12. Milburn DS, Myers CW.

Animal research has shown that the potential for cannabinoid dependence exists, and cannabinoid withdrawal symptoms can be observed. However, both appear to be mild compared to dependence and withdrawal seen with other drugs. • Basic research in cannabinoid biology has revealed a variety of cellular pathways through which potentially therapeutic drugs could act on the cannabinoid system. In addition to the known cannabinoids, such drugs might include chemical derivatives of plantderived cannabinoids or of endogenous cannabinoids such as anandamide but would also include noncannabinoid drugs that act on the cannabinoid system.

CANNABIS AND THE CANNABINOIDS Marijuana is the common name for Cannabis sativa, a hemp plant that grows throughout temperate and tropical climates. 16 But that does not mean there are 66 different cannabinoid effects or interactions. Most of the cannabinoids are closely related; they fall into only 10 Copyright © National Academy of Sciences. All rights reserved. 5 Cannabinoids Identified in Marijuana Cannabinoid Group Common Abbreviation No. 1). Throughout this report, THC is used to indicate ∆9-THC.

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