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Biocompatible Graphene for Bioanalytical Applications by Yuwei Hu, Fenghua Li, Dongxue Han, Li Niu

By Yuwei Hu, Fenghua Li, Dongxue Han, Li Niu

This ebook highlights the newest advances within the use of graphene and bio-compatible-material-decorated graphene to realize a variety of goals (e.g. DNA, RNA, amino acids, peptides, proteins, enzymes, antigens, glucose, DA, AA, UA, ATP, NADH, gasoline, ions, etc.). It specializes in the categorical interplay of those ingredients with graphene (or changed graphene) and the effective transduction of the objective reputation occasion into detectable signs through a variety of thoughts. specific emphasis is given to well-designed techniques for developing graphene-based structures and goal selection. It additionally covers different bio-analytical purposes together with mobile imaging, drug supply and micro organism inhibition, prior to turning to a dialogue of destiny demanding situations and clients of graphene in bio-analytical functions. This e-book is meant for researchers operating within the fields of analytical chemistry, nanomaterials and biomedical engineering.

Li Niu is a Professor on the country Key Laboratory of Electroanalytical Chemistry, Changchun Institute of utilized Chemistry, chinese language Academy of Sciences.

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Ed. 47, 6681–6684 (2008) References 31 52. : Electrochemical sensing and biosensing platform based on chemically reduced graphene oxide. Anal. Chem. 81, 5603–5613 (2009) 53. : Stacked graphene nanofibers for electrochemical oxidation of DNA bases. Phys. Chem. Chem. Phys. 12, 8943–8947 (2010) 54. : Direct voltammetric detection of DNA and pH sensing on epitaxial graphene: an insight into the role of oxygenated defects. Anal. Chem. 82, 7387–7393 (2010) 55. : Toward single-DNA electrochemical biosensing by graphene nanowalls.

3 RNA Detection Like DNA, RNA is assembled as a chain of nucleotides (G, A, U, C), but is usually single stranded. MicroRNAs (miRNAs) are small, endogenous, non-coding RNAs (approximately 18–25 nucleotides), which play crucial roles in cell proliferation, differentiation, and apoptosis. The sensitive, rapid, and multiple miRNA detection is of great importance. Similar to the above-mentioned fluorescent DNA detection strategies, firstly, ssDNAs labeled with different dyes are adsorbed on GO, where 28 2 Graphene for DNA Biosensing minimal fluorescence is observed.

Nanopore-based single-molecule DNA analysis. Nanomedicine 2, 459–481 (2007) 87. : Rapid electronic detection of probe-specific microRNAs using thin nanopore sensors. Nat. Nanotechnol. 5, 807–814 (2010) 88. : Continuous base identification for single-molecule nanopore DNA sequencing. Nat. Nanotechnol. 4, 265–270 (2009) 89. : Graphene opens up to DNA. Nat. Nanotechnol. 5, 697–698 (2010) 90. : Graphene as a subnanometre trans-electrode membrane. Nature 467, 190–193 (2010) 91. , Soni, G. : The potential and challenges of nanopore sequencing.

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