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Biomedical Research and Integrated Biobanking: An Innovative by Massimiliano Izzo

By Massimiliano Izzo

This doctoral thesis studies on an cutting edge info repository supplying adaptive metadata administration to maximize info sharing and comprehension in multidisciplinary and geographically allotted collaborations. It ways metadata as a fluid, loosely dependent and dynamical approach instead of a set product, and describes the advance of a singular info administration platform in line with a schemaless JSON facts version, which represents the 1st totally JSON-based metadata repository designed for the biomedical sciences. effects bought in a variety of program eventualities (e.g. built-in biobanking, practical genomics and computational neuroscience) and corresponding functionality checks are mentioned on intimately. final yet now not least, the publication bargains a scientific assessment of information systems widely used within the biomedical sciences, including a clean standpoint at the position of and instruments for info sharing and heterogeneous facts integration in modern biomedical research.

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7. The data provenance module monitors the origins of data and the processing steps. It allows repetition of processing workflows to test the results’ replication. 3 Metadata Standardisation 19 8. A terminology component adds semantic content to the elements’ content, linking them to terms within a terminology. Given the main focus on neuroscience experiments, there is support for Brain Atlases and ontologies deputed to largescale experimental annotation. 4 The Shortcomings of Standards in Research Collaborations In any real-life scenario—and biomedical research is no exception—standards take time to develop.

Many binding tools have been developed for Java, which is the language adopted by many of the biomedical repositories: the most popular are JAXB, JiBX, and XMLBeans; C++ offers CodeSynthesis XSD. With XML, data must be put within some document structure and this can be complicated with elements that can be nested, attributes that cannot be nested and complex types with their own peculiarities. When trying to develop a data model compliant with modern object-oriented languages, a software engineer should evaluate other solutions besides XML.

3(3), research0046 (2002) 17. : The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin. Chem. 55(4), 611–622 (2009) 18. : Guidelines for reporting an fMRI study. Neuroimage 40(2), 409–414 (2008) 19.

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