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Bioresorbable Polymers for Biomedical Applications. From by Giuseppe Perale, Jöns Hilborn

By Giuseppe Perale, Jöns Hilborn

Bioresorbable Polymers for Biomedical functions: From basics to Translational Medicine offers readers with an outline of bioresorbable polymeric fabrics within the biomedical box. an invaluable source for fabrics scientists in and academia, delivering details at the basics and concerns, synthesis and processing, and the scientific and R and D purposes of bioresorbable polymers for biomedical applications.

  • Focuses on biomedical purposes of bioresorbable polymers
  • Features a finished diversity of subject matters together with basics, synthesis, processing, and applications
  • Provides balanced insurance of the sphere with contributions from academia and industry
  • Includes medical and R and D functions of bioresorbable polymers for biomedical applications

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Extra resources for Bioresorbable Polymers for Biomedical Applications. From Fundamentals to Translational Medicine

Example text

Important consequences of surface erosion are normally under control. In addition, drug release can be managed as well as the maintenance of an essentially neutral pH inside the matrix because acidic hydrolysis products diffuse away from the device (Park, 2005). 5 Polyphosphazenes Poly[(organo)phosphazenes] are a particular class of extremely versatile polymers adopted for several applications including drug delivery (as hydrogels), shape memory polymers, and stimuli-responsive materials. These materials do not have carbon atoms in their backbone.

If the liquid molecular cohesion is sufficiently high, there is no breakage of the stream (otherwise, droplets are electrosprayed), and a charged liquid jet is produced (Sill, 2008). As the jet dries in flight, the mode of current flow changes from ohmic to convective as the charge moves to the surface of the fiber. 2 Schematic of electrospinning apparatus. Introduction to bioresorbable polymers for biomedical applications 9 is finally deposited on a grounded collector. The elongation and thinning of the fiber resulting from this bending instability lead to the formation of uniform fibers with micro- or nanodiameters (Li, 2004).

Thus, they must be treated to avoid any spontaneous reaction (Dossi, 2010). The polymerization process follows a free radical or anionic/zwitterionic mechanism. The free radical mechanism is characterized by a high value of activation energy (125 k/Jmol); this process is very slow and strongly dependent on temperature and radical amount. The anionic/zwitterionic mechanism is more attractive because it is faster and easier to perform; it also takes place in weak bases. Typical initiators are ionic (eg, IÀ, BrÀ, OHÀ) and nucleophilic compounds.

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